SECURITIES AND EXCHANGE COMMISSION
                              WASHINGTON, DC 20549

                                  SCHEDULE 13G
                                 (Rule 13d-102)


             INFORMATION TO BE INCLUDED IN STATEMENTS FILED PURSUANT
           TO RULES 13d-1(b)(c), AND (d) AND AMENDMENTS THERETO FILED
                            PURSUANT TO RULE 13d-2(b)

                               (AMENDMENT NO. 1)*


                       Oscient Pharmaceuticals Corporation
--------------------------------------------------------------------------------
                                (Name of Issuer)


                    Common Stock, $0.01 par value per share
--------------------------------------------------------------------------------
                         (Title of Class of Securities)


                                   68812R105
                        -------------------------------
                                 (CUSIP Number)


                                December 31, 2006
--------------------------------------------------------------------------------
            (Date of Event Which Requires Filing of this Statement)


Check the  appropriate box to designate the rule pursuant to which this Schedule
is filed:

          [_]  Rule 13d-1(b)
          [X]  Rule 13d-1(c)
          [_]  Rule 13d-1(d)


*The  remainder of this cover page shall be filled out for a reporting  person's
initial filing on this form with respect to the subject class of securities, and
for any  subsequent  amendment  containing  information  which  would  alter the
disclosures provided in a prior cover page.

The information required in the remainder of this cover page shall not be deemed
to be "filed" for the purpose of Section 18 of the  Securities  Exchange  Act of
1934 ("Act") or otherwise  subject to the liabilities of that section of the Act
but  shall be  subject  to all other  provisions  of the Act  (however,  see the
Notes).


SEC 1745 (3-98)





________________________________________________________________________________
1.   NAME OF REPORTING PERSONS
     I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY)


     Abingworth Management Limited
________________________________________________________________________________
2.   CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP*
                                                                 (a)  [_]
                                                                 (b)  [_]

________________________________________________________________________________
3.   SEC USE ONLY



________________________________________________________________________________
4.   CITIZENSHIP OR PLACE OF ORGANIZATION


     England
________________________________________________________________________________
  NUMBER OF    5.   SOLE VOTING POWER

   SHARES           o
               _________________________________________________________________
BENEFICIALLY   6.   SHARED VOTING POWER

  OWNED BY          13,552,052
               _________________________________________________________________
    EACH       7.   SOLE DISPOSITIVE POWER

  REPORTING         0
               _________________________________________________________________
   PERSON      8.   SHARED DISPOSITIVE POWER

    WITH            13,552,052
________________________________________________________________________________
9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON

     13,552,052 shares

________________________________________________________________________________
10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES*

                                                                          [_]

________________________________________________________________________________
11.  PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9

     5.5%

________________________________________________________________________________
12.  TYPE OF REPORTING PERSON*

     CO

________________________________________________________________________________




ITEM 1(a).    NAME OF ISSUER: Oscient Pharmaceuticals Corp. (the "Issuer")

ITEM 1(b).    ADDRESS OF ISSUER'S PRINCIPAL EXECUTIVE OFFICES:

              1000 Winter Street, Suite 2200
              Waltham, Massachusetts 02451

ITEM 2(a).    NAME OF PERSONS FILING: Abingworth Management Limited
              ("Abingworth Management").

ITEM 2(b).    ADDRESS OF PRINCIPAL BUSINESS OFFICE OR, IF NONE, RESIDENCE:
              The business address for Abingworth Management, Princess House,
              38 Jermyn Street, London, England SW1Y 6DN.

ITEM 2(c).    CITIZENSHIP: Abingworth Management is a corporation organized
              under the laws of England.

ITEM 2(d).    TITLE OF CLASS OF SECURITIES: Common Stock, $0.01 par value per
              share

ITEM 2(e).    CUSIP NUMBER: 68812R105

ITEM 3.       IF THIS STATEMENT IS FILED PURSUANT TO RULE 13d-1(b), OR
              13d-2(b) OR (c), CHECK WHETHER THE PERSON FILING IS A:

              Not applicable.

ITEM 4.       OWNERSHIP.

              (a)    Amount Beneficially Owned:

                     Abingworth Management Limited is the manager of Abingworth
                     Bioequities Master Fund LTD, Abingworth Bioventures IV
                     L.P., Abingworth Bioventures IV Executives L.P., Abingworth
                     Bioventures III A L.P., Abingworth Bioventures III B LP,
                     Abingworth Bioventures III C LP and Abingworth Bioventures
                     III Executives LP (collectively, the"Funds").

                     As of the date hereof, Abingworth Bioequities Master Fund
                     LTD is the record owner of 207,292 shares of Common Stock;
                     Abingworth Bioventures IV L.P. is the record owner of
                     186,742 shares of Common Stock; Abingworth Bioventures IV
                     Executives L.P. is the record owner of 1,602 shares of
                     Common Stock; Abingworth Bioventures III A L.P. is the
                     record owner of 81,283 shares of Common Stock; Abingworth
                     Bioventures III B L.P. is the record owner of 49,661 shares
                     of Common Stock; Abingworth Bioventures III C L.P. is the
                     record owner of 29,677 shares of Common Stock; and
                     Abingworth Bioventures III Executives L.P. is the record
                     owner of 1,297 shares of Common Stock.

                     In addition, Abingworth Bioequities Master Fund LTD is the
                     record owner of warrants, exercisable for 56,671 shares of
                     Common Stock; Abingworth Bioventures IV L.P. is the record
                     owner of warrants, exercisable for 56,189 shares of Common
                     Stock; Abingworth Bioventures IV Executives L.P. is the
                     record owner of warrants, exercisable for 482 shares of
                     Common Stock; Abingworth Bioventures III C L.P. is the
                     record owner of warrants, exercisable for 14,838 shares of
                     Common Stock; Abingworth Bioventures III B L.P. is the
                     record owner of warrants, exercisable for



                     24,830 shares of Common Stock; AbingworthBioventures III A
                     L.P. is the record owner of warrants, exercisable for
                     40,641 shares of Common Stock; and Abingworth Bioventures
                     III Executives L.P. is the record owner of warrants,
                     exercisable for 648 shares of Common Stock. All of the
                     warrants held by the Funds are immediately exercisable.

                     As the manager of each of the Funds, Abingworth Management
                     may be deemed to beneficially own 751,853 shares of Common
                     Stock, which represents the shares of Common Stock and the
                     warrants exercisable for shares of Common Stock held by the
                     Funds.

              (b)    Percent of Class: Abingworth Management beneficially owns
                     5.5% of the outstanding Common Stock of the Issuer.

                     The foregoing percentages are calculated based on the
                     13,552,125 shares of Common Stock reported to be
                     outstanding following a one-for-eight reverse stock split
                     as of November 15, 2006 in the Issuer's Form 8-K filed with
                     the Securities Exchange Commission on November 15, 2006.

              (c)    Number of shares as to which such person has:

                        (i) sole power to vote or to direct the vote: see line 5
                        of cover sheets.

                        (ii) shared power to vote or to direct the vote: see
                        line 6 of cover sheets.

                        (iii) sole power to dispose or to direct the
                        disposition: see line 7 of cover sheets.

                        (iv) shared power to dispose or to direct the
                        disposition: see line 8 of cover sheets.

              Each Reporting Person disclaims beneficial ownership of such
              shares of Common Stock except for the shares, if any, such
              Reporting Person holds of record.

ITEM 5.       OWNERSHIP OF FIVE PERCENT OR LESS OF A CLASS.

              Not applicable.

ITEM 6.       OWNERSHIP OF MORE THAN FIVE PERCENT ON BEHALF OF ANOTHER PERSON.

              Not applicable.

ITEM 7.       IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH
              ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING
              COMPANY.

              Not applicable.





ITEM 8.       IDENTIFICATION AND CLASSIFICATION OF MEMBERS OF THE GROUP.

              Not applicable.

ITEM 9.       NOTICE OF DISSOLUTION OF GROUP.

              Not applicable.

ITEM 10.      CERTIFICATION.

              By signing below I certify that, to the best of my knowledge and
              belief, the securities referred to above were not acquired and are
              not held for the purpose of or with the effect of changing or
              influencing the control of the issuer of the securities and were
              not acquired and are not held in connection with or as a
              participant in any transaction having that purpose or effect.





                                    SIGNATURE

         After reasonable inquiry and to the best of my knowledge and belief, I
certify that the information set forth in this statement is true, complete and
correct.

Date:  February 12, 2007



ABINGWORTH MANAGEMENT LIMITED

By:     /s/ DAVID LEATHERS
        ----------------------------------
        Name:    David Leathers
        Title:   Executive Director