Ownership Submission
FORM 4
Check this box if no longer subject to Section 16. Form 4 or Form 5 obligations may continue. See Instruction 1(b).
UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

STATEMENT OF CHANGES IN BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
Neukermans Armand
  2. Issuer Name and Ticker or Trading Symbol
DURECT CORP [DRRX]
5. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
__X__ Director _____ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
(Last)
(First)
(Middle)
10260 BUBB ROAD
3. Date of Earliest Transaction (Month/Day/Year)
06/14/2012
(Street)

CUPERTINO, CA 95014
4. If Amendment, Date Original Filed(Month/Day/Year)
6. Individual or Joint/Group Filing(Check Applicable Line)
_X_ Form filed by One Reporting Person
___ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Acquired, Disposed of, or Beneficially Owned
1.Title of Security
(Instr. 3)
2. Transaction Date (Month/Day/Year) 2A. Deemed Execution Date, if any (Month/Day/Year) 3. Transaction Code
(Instr. 8)
4. Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4 and 5)
5. Amount of Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 3 and 4)
6. Ownership Form: Direct (D) or Indirect (I)
(Instr. 4)
7. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V Amount (A) or (D) Price
Common Stock 06/14/2012   P   100 A $ 0.8242 75,100 I by Trust (1)
Common Stock 06/14/2012   P   400 A $ 0.8299 75,500 I by Trust (1)
Common Stock 06/14/2012   P   200 A $ 0.831 75,700 I by Trust (1)
Common Stock 06/14/2012   P   200 A $ 0.8316 75,900 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8319 76,000 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8332 76,100 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8346 76,200 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8352 76,300 I by Trust (1)
Common Stock 06/14/2012   P   1,000 A $ 0.8355 77,300 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8358 77,400 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8363 77,500 I by Trust (1)
Common Stock 06/14/2012   P   400 A $ 0.8372 77,900 I by Trust (1)
Common Stock 06/14/2012   P   200 A $ 0.8373 78,100 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.838 78,200 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8405 78,300 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.842 78,400 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8431 78,500 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8435 78,600 I by Trust (1)
Common Stock 06/14/2012   P   200 A $ 0.8446 78,800 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8452 78,900 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8456 79,000 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8457 79,100 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8482 79,200 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8484 79,300 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8498 79,400 I by Trust (1)
Common Stock 06/14/2012   P   800 A $ 0.8499 80,200 I by Trust (1)
Common Stock 06/14/2012   P   900 A $ 0.85 81,100 I by Trust (1)
Common Stock 06/14/2012   P   500 A $ 0.8501 81,600 I by Trust (1)
Common Stock 06/14/2012   P   400 A $ 0.8501 82,000 I by Trust (1)
Common Stock 06/14/2012   P   100 A $ 0.8502 82,100 I by Trust (1)

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Table II - Derivative Securities Acquired, Disposed of, or Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 3)
2. Conversion or Exercise Price of Derivative Security 3. Transaction Date (Month/Day/Year) 3A. Deemed Execution Date, if any (Month/Day/Year) 4. Transaction Code
(Instr. 8)
5. Number of Derivative Securities Acquired (A) or Disposed of (D)
(Instr. 3, 4, and 5)
6. Date Exercisable and Expiration Date
(Month/Day/Year)
7. Title and Amount of Underlying Securities
(Instr. 3 and 4)
8. Price of Derivative Security
(Instr. 5)
9. Number of Derivative Securities Beneficially Owned Following Reported Transaction(s)
(Instr. 4)
10. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 4)
11. Nature of Indirect Beneficial Ownership
(Instr. 4)
Code V (A) (D) Date Exercisable Expiration Date Title Amount or Number of Shares

Reporting Owners

Reporting Owner Name / Address Relationships
 Director  10% Owner  Officer  Other
Neukermans Armand
10260 BUBB ROAD
CUPERTINO, CA 95014
  X      

Signatures

 Armand P. Neukermans   06/18/2012
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 4(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Held by Neukermans Family Trust u/a/d January 21, 1993

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