Ownership Submission
FORM 3
 UNITED STATES SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549

INITIAL STATEMENT OF BENEFICIAL OWNERSHIP OF SECURITIES

Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934, Section 17(a) of the Public Utility Holding Company Act of 1935 or Section 30(h) of the Investment Company Act of 1940
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(Print or Type Responses)
1. Name and Address of Reporting Person *
  SOON-SHIONG PATRICK
 2. Date of Event Requiring Statement (Month/Day/Year)
12/22/2014		 3. Issuer Name and Ticker or Trading Symbol
Sorrento Therapeutics, Inc. [SRNE]
(Last)
(First)
(Middle)
9922 JEFFERSON BOULEVARD		 4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
_____ Director __X__ 10% Owner
_____ Officer (give title below) _____ Other (specify below)
5. If Amendment, Date Original Filed(Month/Day/Year)
(Street)

CULVER CITY, CA 90232		 6. Individual or Joint/Group Filing(Check Applicable Line)
___ Form filed by One Reporting Person
_X_ Form filed by More than One Reporting Person
(City)
(State)
(Zip)
Table I - Non-Derivative Securities Beneficially Owned
1.Title of Security
(Instr. 4)		 2. Amount of Securities Beneficially Owned
(Instr. 4)		 3. Ownership Form: Direct (D) or Indirect (I)
(Instr. 5)		 4. Nature of Indirect Beneficial Ownership
(Instr. 5)
Common Stock 720,174
D
 
Common Stock 7,188,061
I
Through Cambridge Equities, LP (1)

Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly. SEC 1473 (7-02)
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Table II - Derivative Securities Beneficially Owned (e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security
(Instr. 4)		 2. Date Exercisable and Expiration Date
(Month/Day/Year)		 3. Title and Amount of Securities Underlying Derivative Security
(Instr. 4)		 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form of Derivative Security: Direct (D) or Indirect (I)
(Instr. 5)		 6. Nature of Indirect Beneficial Ownership
(Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Warrant 12/22/2014 12/22/2017 Common Stock 1,724,138 $ 5.8 (2) I Through Cambridge Equities, LP (1)

Reporting Owners

Reporting Owner Name / Address Relationships
Director 10% Owner Officer Other
SOON-SHIONG PATRICK
9922 JEFFERSON BOULEVARD
CULVER CITY, CA 90232		     X    
MP 13 Ventures, LLC
9922 JEFFERSON BOULEVARD
CULVER CITY, CA 90232		     X    
Cambridge Equities, LP
9922 JEFFERSON BOULEVARD
CULVER CITY, CA 90232		     X    

Signatures

/s/ Patrick Soon-Shiong 12/29/2014
**Signature of Reporting Person Date
/s/ Charles Kenworthy, Manager of MP 13 Ventures, on behalf of itself and as General Partner of Cambridge Equities 12/29/2014
**Signature of Reporting Person Date

Explanation of Responses:

* If the form is filed by more than one reporting person, see Instruction 5(b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations. See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
(1) Dr. Patrick Soon-Shiong is the sole member of MP 13 Ventures, LLC ("MP 13 Ventures"), which is the general partner of Cambridge Equities, LP ("Cambridge Equities").
(2) The exercise price of the Warrant is subject to customary adjustment provisions for stock splits, stock dividends, recapitalizations and the like.
 
Remarks:
Each of the reporting persons hereunder disclaims beneficial ownership of the reported securities except to the extent of its or his pecuniary interests therein. This Form 3 shall not be deemed to be an admission that any reporting person hereunder is the beneficial owner of any of the reported securities for purposes of Section 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.

Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, See Instruction 6 for procedure.

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