CUSIP No. |
13738Y107 |
13G | Page | 2 |
of | 8 Pages |
1 | NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) INTERNATIONAL BIOTECHNOLOGY TRUST PLC |
||||
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) |
||||
(a) o | |||||
(b) o | |||||
3 | SEC USE ONLY | ||||
4 | CITIZENSHIP OR PLACE OF ORGANIZATION | ||||
UNITED KINGDOM | |||||
5 | SOLE VOTING POWER | ||||
NUMBER OF | -0- | ||||
SHARES | 6 | SHARED VOTING POWER | |||
BENEFICIALLY | |||||
OWNED BY | 1,907,390 | ||||
EACH | 7 | SOLE DISPOSITIVE POWER | |||
REPORTING | |||||
PERSON | -0- | ||||
WITH: | 8 | SHARED DISPOSITIVE POWER | |||
1,907,390 | |||||
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | ||||
1,907,390 | |||||
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) | ||||
o | |||||
11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | ||||
4.7% | |||||
12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) | ||||
CO |
CUSIP No. |
29425Y101 |
13G | Page | 3 |
of | 8 Pages |
1 | NAMES OF REPORTING PERSONS I.R.S. IDENTIFICATION NOS. OF ABOVE PERSONS (ENTITIES ONLY) SV LIFE SCIENCES MANAGERS LLP |
||||
2 | CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP (SEE INSTRUCTIONS) |
||||
(a) o | |||||
(b) o | |||||
3 | SEC USE ONLY | ||||
4 | CITIZENSHIP OR PLACE OF ORGANIZATION | ||||
UNITED KINGDOM | |||||
5 | SOLE VOTING POWER | ||||
NUMBER OF | -0- | ||||
SHARES | 6 | SHARED VOTING POWER | |||
BENEFICIALLY | |||||
OWNED BY | 1,907,390 | ||||
EACH | 7 | SOLE DISPOSITIVE POWER | |||
REPORTING | |||||
PERSON | -0- | ||||
WITH: | 8 | SHARED DISPOSITIVE POWER | |||
1,907,390 | |||||
9 | AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING PERSON | ||||
1,907,390 | |||||
10 | CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES CERTAIN SHARES (SEE INSTRUCTIONS) | ||||
o | |||||
11 | PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW 9 | ||||
4.7% | |||||
12 | TYPE OF REPORTING PERSON (SEE INSTRUCTIONS) | ||||
PN |
CUSIP No. 29425Y101 | 13G | Page 4 of 8 Pages | ||
(i) | International Biotechnology Trust plc (IBT); and | ||
(ii) | SV Life Sciences Managers LLP (Managers). |
CUSIP No. 29425Y101 | 13G | Page 5 of 8 Pages | ||
(a) | Amount beneficially owned: 1,907,390 shares of Common Stock | ||
(b) | Percent of class: 4.7% | ||
(c) | Number of shares as to which such person has: |
(i) | Sole power to vote or to direct the vote: -0- | ||
(ii) | Shared power to vote or to direct the vote: 1,907,390 | ||
(iii) | Sole power to dispose or to direct the disposition of: -0- | ||
(iv) | Shared power to dispose or to direct the disposition of: 1,907,390 |
ITEM 7. | IDENTIFICATION AND CLASSIFICATION OF THE SUBSIDIARY WHICH ACQUIRED THE SECURITY BEING REPORTED ON BY THE PARENT HOLDING COMPANY. |
CUSIP No. 29425Y101 | 13G | Page 6 of 8 Pages | ||
CUSIP No. 29425Y101 | 13G | Page 7 of 8 Pages | ||
February 14, 2008 | ||||
Date | ||||
INTERNATIONAL BIOTECHNOLOGY TRUST PLC | ||||
/s/ Nick Coleman
|
||||
Signature | ||||
Nick Coleman, Authorized Signatory | ||||
Name/Title | ||||
SV LIFE SCIENCES MANAGERS LLP | ||||
/s/ Nick Coleman | ||||
Signature | ||||
Nick Coleman, Authorized Signatory | ||||
Name/Title |
CUSIP No. 29425Y101 | 13G | Page 8 of 8 Pages | ||
Exhibit 1.
|
Joint Filing Agreement as required by Rule 13d-1(k)(1) under the Securities Exchange Act of 1934, as amended.* |