Prepared by R.R. Donnelley Financial -- Prospectus Supplement
Table of Contents
 
Filed Pursuant to Rule 424B(5)
Registration No. 333-52696
 
Prospectus Supplement to Prospectus dated December 22, 2000.
 
464,437 Shares
 
Medarex, Inc.
 
Common Stock
 
 
Medarex is offering 464,437 shares of its common stock all of which will be issued directly to Corixa Corporation in exchange for certain assets of Corixa.
 
The number of shares to be issued and delivered to Corixa will be determined by dividing $3,500,000, an amount representing one-sixth of $21,000,000, the value of the assets we acquired from Corixa on May 23, 2002, by $7.536, the average of the closing sales prices of our common stock for each of the five trading days commencing on July 15, 2002 and ending on July 19, 2002.
 
Our common stock is quoted on the Nasdaq National Market under the symbol “MEDX.” The last reported sale price for the common stock on July 24, 2002 was $7.22 per share.
 
 
Investing in our common stock involves certain risks. See “Risk Factors” beginning on page S-9 of this prospectus supplement to read about important factors you should consider before investing in our common stock.
 
 
Neither the Securities and Exchange Commission nor any other regulatory body has approved or disapproved of these securities or passed upon the accuracy or adequacy of this prospectus. Any representation to the contrary is a criminal offense.
 
 
The shares of common stock offered hereby are being issued directly to Corixa on the date hereof. No discounts, commissions, concessions or other compensation has been paid to any underwriter, broker, dealer or agent in connection with the offering.
 
 
Prospectus Supplement dated July 25, 2002

Table of Contents
 
FORWARD-LOOKING STATEMENTS
 
This prospectus supplement includes or incorporates by reference forward-looking statements, including those identified by the words “believes,” “anticipates,” “expects” and similar expressions. Medarex has based these forward-looking statements on its current expectations and projections about future events. These forward-looking statements are subject to risks, uncertainties and assumptions, including among other things:
 
 
•
 
uncertainties relating to the technological approach;
 
 
•
 
history of operating losses and anticipation of future losses;
 
 
•
 
uncertainty of product development, need for additional capital and uncertainty of change;
 
 
•
 
uncertainty of patent and propriety rights;
 
 
•
 
management of growth, and risks of acquiring new technologies;
 
 
•
 
uncertainties related to clinical trials;
 
 
•
 
government regulation and uncertainty of obtaining regulatory approval;
 
 
•
 
dependence on key personnel;
 
 
•
 
dependence on research collaborators and scientific advisors;
 
 
•
 
uncertainty of health care reform measures; and
 
 
•
 
third-party reimbursement and risk of product liability.
 
Medarex undertakes no obligation to publicly update or revise any forward-looking statements, whether as a result of new information, future events or otherwise. In light of these risks, uncertainties and assumptions, the forward-looking events discussed in the prospectus supplement, the accompanying prospectus and in the incorporated documents might not occur.
 
 
You should rely only on the information contained or incorporated by reference in this prospectus supplement and the accompanying prospectus. Medarex has not authorized any other person to provide you with different information. If anyone provides you with different or inconsistent information, you should not rely on it. Medarex is not making an offer to sell these securities in any jurisdiction where the offer or sale is not permitted. You should assume that the information contained or incorporated by reference in this prospectus supplement and the accompanying prospectus is accurate as of the date on the front cover of each such prospectus only. The business, financial condition, results of operations and prospects of Medarex may have changed since such dates.
 
 
Medarex® and HuMAb-Mouse® are registered U.S. trademarks of Medarex, Inc. UltiMAb™, UltiMAb Human Antibody Development SystemSM, KM-Mouse™ and Trans-Phage Technology™ are trademarks or service marks of Medarex, Inc. All other company names, trademarks and service marks included herein are trademarks, registered trademarks, service marks or trade names of their respective owners.

S-2

Table of Contents
 
THE COMPANY
 
We are a biopharmaceutical company focused on the discovery and development of human antibody-based therapeutic products. Our UltiMAb Human Antibody Development SystemSM enables us to rapidly create and develop therapeutic products for a wide range of potential diseases, including cancer, inflammation, auto-immune disease and other life-threatening and debilitating diseases.
 
We believe that antibodies are proven candidates for therapeutic products. To date, the United States Food and Drug Administration, or FDA, has approved eleven antibody-based therapeutic products for sale in the United States. During the past three years, these products generated aggregate worldwide sales in excess of $6 billion, with sales doubling from 1999 to 2001. We intend to participate in this market, and to this end, are developing an expanding pipeline of therapeutic antibody products developed through the use of our proprietary UltiMAb™ technology. Multiple therapeutic products generated using our technology are in various stages of human clinical trials, including several of which we are developing using our own resources and others where we have licensed our technology to our partners for their use in the development of their products. We and our partners also have a number of product candidates in preclinical development.
 
As of July 15, 2002, 42 pharmaceutical and biotechnology companies have partnered with us to jointly develop and commercialize products or have otherwise acquired rights to use our proprietary technology in their development of new therapeutic products. These companies include industry leaders such as Amgen, Inc., Centocor, Inc. (a subsidiary of Johnson & Johnson), Eli Lilly & Company, Human Genome Sciences, Inc., Immunex Corporation, Novartis Pharma AG, Novo Nordisk A/S and Schering AG. Some of these are licensing partnerships, providing us with licensing fees, milestone payments and royalty payments; others are collaborative partnerships that provide for the sharing of product development costs, revenues, expenses and profits.
 
In addition to our UltiMAb Human Antibody Development System, we have considerable experience in preclinical and clinical development as well as in manufacturing antibodies for clinical trials. Our existing manufacturing facility in Annandale, New Jersey currently has the capacity to produce up to approximately 10 kilograms of monoclonal antibodies per year for clinical development purposes. We are implementing a strategy that contemplates increased developmental capacity, together with potential outside contract manufacturing for large-scale clinical production. We have assembled a team of experienced scientific, production, clinical and regulatory personnel to facilitate the discovery, development and commercialization of antibody-based products for us and for our partners. We intend to add sales and marketing and additional manufacturing capabilities as needed.
 
Our goal is to be a leader in the discovery and development of human antibody-based therapeutics for the treatment of cancer and other life-threatening and debilitating diseases. To this end, we have implemented a business strategy involving the expansion and diversification of our product pipeline and partnerships and an increase in our resources to develop, manufacture and commercialize products. We intend to capitalize on the value of our own human antibody products by developing them through late stage clinical trials and/or regulatory approval. We believe this will allow us to retain substantial commercial rights or profit sharing opportunities with regard to these products. In addition, we are enhancing and expanding our partnerships, which provides us the opportunity to participate in the development of substantially more product candidates than we could develop using only our own resources. We believe our business strategy will allow us to capitalize on our broad range of product development capabilities thereby maximizing the value of our business.

S-3

Table of Contents
 
RECENT DEVELOPMENTS
 
On May 23, 2002, we and our subsidiary, Medarex Belgium, S.A., entered into an Asset Purchase Agreement with Corixa, Coulter Pharmaceutical, Inc. a wholly owned subsidiary of Corixa and Corixa Belgium S.A., a subsidiary of Corixa. Corixa, Coulter Pharmaceutical and Corixa Belgium are hereinafter collectively referred to as Corixa. Under the terms of the Asset Purchase Agreement, we acquired certain selected assets and related business operations of Corixa, including certain preclinical product candidates and programs related to the research and development of therapeutic products for the treatment of autoimmune diseases, cancer and infectious diseases. As part of this transaction, we also acquired all intellectual property, know-how, data, contracts, equipment and materials owned or licensed by Corixa related to such product candidates and programs, as well as all research and development activities, regulatory approval processes and permits, manufacturing, marketing and distribution activities, and the conduct of clinical trials with respect thereto. In addition, we agreed to sublease approximately 30,000 square feet of laboratory and office space at Corixa’s South San Francisco, California facility. We also assumed certain additional liabilities and agreed to retain approximately 30 Corixa employees related to such product candidates and programs.
 
We acquired the assets for an aggregate purchase price consisting of (1) six equal monthly installments of $3,500,000, payable in cash, or at our election, in shares of our common stock (the first payment was made at the closing of the acquisition in the form of 356,706 fully registered shares of our common stock, the second payment of 427,455 fully registered shoes was made on June 27, 2002 and the remaining four payments are to be made each month thereafter), and (2) $2.5 million in cash for certain equipment and laboratory supplies. We also reimbursed Corixa for certain expenses it incurred in connection with the transferred business operations. If we decide to make a monthly installment payment in shares of our common stock, the number of shares of common stock subject to issuance each month in connection with each installment payment will be determined by dividing (x) $3,500,000 by (y) the average of the closing sales prices of our common stock for each of the trading days during the five-trading-day period ending two trading days prior to the applicable date of issuance as publicly reported on Nasdaq. In the event that, during any month during the six-month period following the closing of the transaction, Corixa sells all of the shares of our common stock delivered as payment for the preceding monthly installment and the proceeds of such sale are less than $3,500,000, we must pay the difference to Corixa in cash. If such sale proceeds are greater than $3,500,000, Corixa must pay us an amount equal to 50% of any such excess in cash. In the event that, during any month during the six-month period, Corixa does not sell all of the shares of our common stock delivered as payment of the preceding monthly installment, then there will be no such adjustments. In addition, Corixa may receive up to an additional $6 million in additional consideration in cash or, at our election, in shares of common stock, based upon certain contingencies. If we are required to make any contingent payment to Corixa and we decide to make such payment in shares of our common stock, then the number of shares subject to issuance in connection with the contingent payment will be determined by dividing the applicable contingent amount by the average of the closing sales prices of our common stock for each of the trading days during the five trading day period ending two trading days prior to the applicable date of issuance of such shares as reported on Nasdaq.
 
All shares of our common stock issued as payment of the purchase price will be fully registered and freely tradable, provided, however, that Corixa has agreed that it will not sell more than 50% of the total number of shares constituting a monthly installment payment in any five-trading-day period.

S-4

Table of Contents
 
THE OFFERING
 
Common Stock Offered
  
464,437
Common Stock to be outstanding after the offering
  
75,345,614
Use of Proceeds
  
We will not receive any cash proceeds from the issuance of the shares of our common stock pursuant to this offering. We have received certain assets from Corixa, including intellectual property, know-how, data, contracts and materials owned or licensed by Corixa related to certain product candidates and programs.
Nasdaq National Market Symbol
  
MEDX
 
Unless otherwise stated herein, all information contained in this prospectus supplement relating to the number of outstanding shares of our common stock excludes:
 
 
•
 
9,744,331 shares of common stock issuable upon exercise of outstanding options having a weighted average exercise price of $13.99 per share;
 
 
•
 
1,760,600 shares of common stock reserved for issuance under our existing stock option plans;
 
 
•
 
500,000 shares of common stock reserved for issuance under our new 2002 Employee Stock Purchase Plan;
 
 
•
 
6,067,961 shares of common stock reserved for issuance upon conversion of $175,000,000 aggregate principal amount of our 4.50% Convertible Subordinated Notes due 2006; and
 
 
•
 
946,330 shares of common stock held in treasury.
 
In addition, the information contained in this prospectus supplement does not include shares of our common stock which we may be required to issue pursuant to certain contractual obligations and shares we may issue under a shelf registration statement on Form S-3 which we have filed under the Securities Act relating to the sale of up to $314.5 million of our securities, all as more fully described herein under the section entitled “Risk Factors.”

S-5

Table of Contents
 
SELECTED CONSOLIDATED FINANCIAL DATA
 
The following table sets forth selected consolidated financial information. The selected consolidated financial information for each of the years in the five-year period ended December 31, 2001 and at December 31 of each of those years has been derived from our audited consolidated financial statements. The financial information set forth below for all other periods presented has been derived from unaudited consolidated financial information, which we believe presents fairly such consolidated information in conformity with generally accepted accounting principles. You should read the selected consolidated financial information in conjunction with our consolidated financial statements and the notes thereto and the other financial information incorporated by reference herein.
 
    
For the Year Ended December 31,
     
For the Three Months Ended March 31,
  
    
1997
     
1998
     
1999
     
2000
     
2001
     
2001
     
2002
  
    
(in thousands, except share and per share data)
     
(unaudited)
     
(unaudited)
  
                         
(Restated)
                       
Statement of Operations Data:
                                                               
Revenues:
                                                               
Sales
   
$
221
 
   
$
1,349
 
   
$
1,079
 
   
$
264
 
   
$
191
 
   
$
66
 
   
$
100
 
Contract and license revenues
   
 
3,011
 
   
 
5,443
 
   
 
8,593
 
   
 
19,619
 
   
 
37,140
 
   
 
8,104
 
   
 
7,613
 
Sales, contract and license revenues from Genmab
   
 
—  
 
   
 
—  
 
   
 
252
 
   
 
2,574
 
   
 
4,973
 
   
 
750
 
   
 
3,058
 
    
  
  
  
  
  
  
Total revenues
   
 
3,232
 
   
 
6,792
 
   
 
9,924
 
   
 
22,457
 
   
 
42,304
 
   
 
8,920
 
   
 
10,771
 
Costs and expenses:
                                                               
Cost of sales
   
 
150
 
   
 
1,218
 
   
 
709
 
   
 
1,189
 
   
 
642
 
   
 
28
 
   
 
1,477
 
Research and development
   
 
14,100
 
   
 
23,122
 
   
 
19,929
 
   
 
33,942
 
   
 
38,626
 
   
 
8,060
 
   
 
17,254
 
General and administrative
   
 
3,644
 
   
 
5,065
 
   
 
8,036
 
   
 
18,142
 
   
 
19,344
 
   
 
3,602
 
   
 
5,418
 
Stock bonus to GenPharm employees
   
 
2,275
 
   
 
    —  
 
   
 
—  
 
   
 
—  
 
   
 
—  
 
   
 
—
 
   
 
—
 
Acquisition of in-process technology
   
 
40,316
 
   
 
—  
 
   
 
—
 
   
 
—
 
   
 
—
 
   
 
—
 
   
 
—
 
    
  
  
  
  
  
  
Total costs and expenses
   
 
60,485
 
   
 
29,405
 
   
 
28,674
 
   
 
53,273
 
   
 
58,612
 
   
 
11,690
 
   
 
24,149
 
    
  
  
  
  
  
  
Operating loss
   
 
(57,254
)
   
 
(22,613
)
   
 
(18,750
)
   
 
(30,816
)
   
 
(16,308
)
   
 
(2,770
)
   
 
(13,378
)
Equity in net loss of affiliate
   
 
—  
 
   
 
—  
 
   
 
—  
 
   
 
(353
)
   
 
(7,334
)
   
 
(577
)
   
 
(3,589
)
Interest and dividend income
   
 
1,903
 
   
 
1,956
 
   
 
1,205
 
   
 
21,158
 
   
 
24,728
 
   
 
6,771
 
   
 
4,946
 
Impairment loss on investments
   
 
—
 
   
 
—
 
   
 
—
 
   
 
—
 
   
 
—
 
   
 
—
 
   
 
(1,600
)
Interest expense
   
 
(27
)
   
 
(1,539
)
   
 
(8
)
   
 
(3
)
   
 
(4,615
)
   
 
(1
)
   
 
(2,218
)
Gain on disposition of Genmab stock
   
 
—  
 
   
 
—  
 
   
 
—
 
   
 
—  
 
   
 
1,442
 
   
 
—  
 
   
 
—  
 
    
  
  
  
  
  
  
Loss before provision (benefit) for income taxes
   
 
(55,377
)
   
 
(22,196
)
   
 
(17,553
)
   
 
(10,014
)
   
 
(2,087
)
   
 
3,423
 
   
 
(15,839
)
Provision (benefit) for income taxes
   
 
—
 
   
 
341
 
   
 
(522
)
   
 
(13,075
)
   
 
600
 
   
 
150
 
   
 
—  
 
    
  
  
  
  
  
  
Net income (loss)
   
$
(55,377
)
   
$
(22,537
)
   
$
(17,031
)
   
$
3,061
 
   
$
(2,687
)
   
 
3,273
 
   
 
(15,839
)
    
  
  
  
  
  
  
Basic net income (loss) per share (1)
   
$
(1.47
)
   
$
(0.44
)
   
$
(0.27
)
   
$
0.04
 
   
$
(0.04
)
   
$
0.04
 
   
$
(0.21
)
    
  
  
  
  
  
  
Diluted net income (loss) per share (1)
   
$
(1.47
)
   
$
(0.44
)
   
$
(0.27
)
   
$
0.04
 
   
$
(0.04
)
   
$
0.04
 
   
$
(0.21
)
    
  
  
  
  
  
  
Weighted average common shares outstanding (1)
                                                               
—basic
   
 
37,742
 
   
 
50,780
 
   
 
63,840
 
   
 
71,532
 
   
 
73,937
 
   
 
73,858
 
   
 
74,011
 
—diluted
   
 
37,742
 
   
 
50,780
 
   
 
63,840
 
   
 
73,232
 
   
 
73,937
 
   
 
75,828
 
   
 
74,011
 
 
       
 
    
1997
     
December 31,
1998
     
1999
     
2000
     
2001
          
March 31, 2002
  
    
(in thousands)
          
(unaudited)
  
                         
(Restated)
                     
Balance Sheet Data:
                                                           
Cash, cash equivalents and marketable securities
   
$
28,444
 
   
$
34,664
 
   
$
30,147
 
   
$
343,603
 
   
$
466,952
 
        
$
428,030
 
Working capital
   
 
1,647
 
   
 
29,581
 
   
 
22,382
 
   
 
329,807
 
   
 
447,326
 
        
 
423,673
 
Total assets
   
 
48,695
 
   
 
42,235
 
   
 
40,482
 
   
 
558,107
 
   
 
720,427
 
        
 
683,717
 
Long term obligations
   
 
107
 
   
 
62
 
   
 
23
 
   
 
—
 
   
 
175,000
 
        
 
175,000
 
Cash dividends declared per common share
   
 
—  
 
   
 
—  
 
   
 
—  
 
   
 
—  
 
   
 
—  
 
        
 
—  
 
Accumulated deficit
   
 
(86,869
)
   
 
(109,405
)
   
 
(126,436
)
   
 
(123,375
)
   
 
(126,062
)
        
 
(141,901
)
Total shareholders’ equity
   
 
5,681
 
   
 
35,229
 
   
 
22,299
 
   
 
485,289
 
   
 
482,562
 
        
 
463,374
 
(1)
 
Computed on the basis described in Note 2 to the Consolidated Financial Statements.

S-6

Table of Contents
 
PRICE RANGE OF COMMON STOCK
 
Our common stock is listed on the Nasdaq National Market under the symbol “MEDX.” The following table sets forth the high and low sale prices per share of our common stock, as reported on the Nasdaq National Market, during the periods indicated.
 
    
Common Stock Price*
    
High
   
Low
Year ended December 31, 2000
              
First Quarter
   
$
103.00
   
$
14.19
Second Quarter
   
$
44.44
   
$
16.63
Third Quarter
   
$
59.94
   
$
35.69
Fourth Quarter
   
$
75.00
   
$
30.06
Year ended December 31, 2001
              
First Quarter
   
$
42.50
   
$
12.06
Second Quarter
   
$
32.25
   
$
11.75
Third Quarter
   
$
24.47
   
$
11.91
Fourth Quarter
   
$
25.05
   
$
14.25
Year ended December 31, 2002
              
First Quarter
   
$
18.34
   
$
13.31
Second Quarter
   
$
16.83
   
$
6.71
Third Quarter (through July 24)
   
$
9.00
   
$
6.10
*
 
All prices have been adjusted to reflect a two-for-one stock split as of September 27, 2000.
 
The number of shares of our common stock outstanding as of July 15, 2002 was 74,881,177. As of April 5, 2002, the record date for our last annual meeting of shareholders held on May 22, 2002, there were approximately 433 record holders of common stock (which includes individual holders) and approximately 23,650 beneficial shareholders of our common stock.
 
We currently expect to retain our future earnings, if any, for use in the operation and expansion of our business and do not anticipate paying any cash dividends in the foreseeable future.
 
DIVIDEND POLICY
 
We have never declared or paid cash dividends. We do not anticipate declaring or paying cash dividends in the foreseeable future. Instead, we will reclaim our earnings, if any, for the future operation and expansion of our business.

S-7

Table of Contents
 
CAPITALIZATION
 
The following table shows our total current assets, total assets, total current liabilities and capitalization at March 31, 2002 (i) on an actual basis, and (ii) on an as adjusted basis giving effect to our acquisition of certain assets from Corixa as described herein under the section entitled “Recent Developments.” You should also refer to our consolidated financial statements and the related notes incorporated by reference herein.
 
    
March 31, 2002
  
    
Actual
     
As Adjusted(1)
  
    
(Dollars in thousands) (Unaudited)
  
Current assets:
                  
Cash and cash equivalents
   
$
50,010
 
   
$
47,510
 
Marketable securities
   
 
378,020
 
   
 
378,020
 
Other current assets
   
 
24,109
 
   
 
24,109
 
    
  
Total current assets
   
 
452,139
 
   
 
449,639
 
    
  
Total assets
   
 
683,717
 
   
 
683,362
 
    
  
Total current liabilities
   
 
28,466
 
   
 
38,966
 
Deferred contract revenue – long term
   
 
1,195
 
   
 
1,195
 
Deferred income taxes and other long term obligations
   
 
15,682
 
   
 
15,682
 
4.50% Convertible Subordinated Notes due 2006
   
 
175,000
 
   
 
175,000
 
Shareholders’ equity
                  
Preferred stock, $1.00 par value, 2,000 shares authorized; none issued and outstanding
   
 
—  
 
   
 
—  
 
Common stock, $.01 par value; 200,000,000 shares authorized; 74,017,416 shares issued and 72,926,061 shares outstanding actual and 75,266,014 issued and 74,174,659 outstanding as adjusted(2)
   
 
740
 
   
 
753
 
Capital in excess of par value
   
 
570,736
 
   
 
581,223
 
Treasury stock, at cost, 1,091,355 shares
   
 
(2,745
)
   
 
(2,745
)
Deferred compensation
   
 
1,768
 
   
 
1,768
 
Accumulated other comprehensive income
   
 
34,776
 
   
 
34,776
 
Accumulated deficit
   
 
(141,901
)
   
 
(163,256
)
    
  
Total shareholders’ equity
   
 
463,374
 
   
 
452,519
 
    
  
Total liabilities and shareholders’ equity
   
 
683,717
 
   
 
683,362
 
    
  
(1)
 
The “As Adjusted” column reflects: (i) the issuance of a total of 1,248,598 shares of our common stock, valued at $10,500,000, representing one-half of the $21,000,000 purchase price; (ii) an accrual of $10,500,000, representing the remaining purchase price which will be paid to Corixa in three remaining installments of $3,500,000 each, which, at our option, may be paid in either cash or in shares of our common stock; (iii) the estimated write-off of the entire $21,000,000 purchase price as in-process research and development; and (iv) the payment of $2,500,000 in cash for certain equipment and laboratory supplies of which approximately $2,145,000 will be capitalized and the remaining $355,000 will be expensed. The allocation of the $21,000,000 purchase price is subject to an independent third party valuation (to be performed) and is, therefore, subject to change. The “As Adjusted” column does not reflect any consideration to be paid based upon certain contingencies and does not reflect any adjustments related to possible cash payments or cash receipts arising from the sale proceeds by Corixa as described under the section herein entitled “Recent Developments.”
(2)
 
Unless otherwise stated herein, all information contained in this prospectus supplement relating to the number of outstanding shares of our common stock excludes:
 
 
•
 
9,744,331 shares of common stock issuable upon exercise of outstanding options having a weighted average exercise price of $13.99per share;
 
 
•
 
1,760,600 shares of common stock reserved for issuance under our existing stock option plans;
 
 
•
 
500,000 shares of common stock reserved for issuance under our new 2002 Employee Stock Purchase Plan;
 
 
•
 
6,067,961 shares of common stock reserved for issuance upon conversion of $175,000,000 aggregate principal amount of our 4.50% Convertible Subordinated Notes due 2006; and
 
 
•
 
946,330 shares of common stock held in treasury.
 
In addition, the information contained in this prospectus supplement does not include shares of our common stock which we may be required to issue pursuant to certain contractual obligations and shares we may issue under a shelf registration statement on Form S-3 we have filed under the Securities Act relating to the sale of up to $314.5 million of our securities, all as more fully described herein under the section herein entitled “Risk Factors.”

S-8

Table of Contents
 
RISK FACTORS
 
This prospectus supplement contains forward-looking statements within the meaning of Sections 27A and 21E of the Securities Exchange Act of 1934, as amended, including statements regarding our expectations, beliefs, intentions, or strategies regarding the future. Forward-looking statements include, without limitation, statements in “Risk Factors” and elsewhere in this prospectus supplement regarding, among other things, uncertainties relating to our technology; history of operating losses and anticipation of future losses; uncertainty of product development; need for additional capital and uncertainty of change; uncertainty of patent and proprietary rights; management of growth, and risks of acquiring new technologies; uncertainties related to clinical trials; government regulation and uncertainty of obtaining regulatory approval; dependence on key personnel; dependence on research collaborators and scientific advisors; uncertainty of health care reform measures and third-party reimbursement and risk of product liability. All forward-looking statements included in this prospectus supplement are based on information available to us, as of the date hereof, and we do not assume any obligation to update any such forward-looking statements. Our actual results may differ materially from the results discussed in the forward-looking statements. Among the factors that could cause actual results to differ materially are the factors detailed in “Risk Factors” below. Accordingly, in addition to the other information in this prospectus supplement, the following factors should be considered carefully. References to our products, business, financial results or financial condition should be considered to refer to us and our subsidiaries unless the context otherwise requires.
 
Our product candidates are in early stages of development.
 
Our human antibody technology is a new approach to the generation of antibody-based therapeutic products. Product candidates employing our human antibody technology are in early stages of development. Only a limited number of fully human antibody product candidates employing our human antibody technology have been generated pursuant to our collaborations. Investigational New Drug Applications, or INDs, have been submitted to the United States Food and Drug Administration, or FDA, for only a subset of these candidates, and clinical trials have not yet commenced for all of these candidates. Only one of these product candidates has reached the Phase III clinical trial stage. In addition, we are not aware of any commercialized fully human monoclonal antibody therapeutic products that have been generated from any technologies similar to ours. Product candidates employing our human antibody technology may not advance beyond the early stages of product development or demonstrate clinical safety and effectiveness.
 
Our human antibody technology may not generate antibodies against all the antigens to which it is exposed in an efficient and timely manner, if at all. If our human antibody technology fails to generate antibody product candidates, or if we or our partners do not succeed in the development of products employing our antibody technology, those product candidates may not be approved or commercialized and our business will suffer.
 
Our products are still under development, and no revenues have been generated from their sale.
 
We have entered into corporate partnerships with a number of companies and are seeking additional alliances that will support the costs of developing our portfolio of antibody-based product candidates. The success of these products is dependent upon the efforts of our corporate partners in developing these products in the future. Neither we nor our corporate partners know if any of these products will be effective.
 
Successful development of our products is uncertain.
 
Our development of current and future product candidates is subject to the risks of failure inherent in the development of new pharmaceutical products and products based on new technologies. These risks include:
 
 
•
 
delays in product development, clinical testing or manufacturing;
 
 
•
 
unplanned expenditures in product development, clinical testing or manufacturing;

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•
 
failure in clinical trials or failure to receive regulatory approvals;
 
 
•
 
emergence of superior or equivalent products;
 
 
•
 
inability to manufacture on our own, or through others, product candidates on a commercial scale;
 
 
•
 
inability to market products due to third-party proprietary rights;
 
 
•
 
election by our collaborative partners not to pursue product development;
 
 
•
 
failure by our collaborative partners to develop products successfully; and
 
 
•
 
failure to achieve market acceptance.
 
Because of these risks, our research and development efforts or those of our licensing partners may not result in any commercially viable products. If a significant portion of these development efforts is not successfully completed, required regulatory approvals are not obtained or any approved products are not commercially successful, our business, financial condition and results of operations may be materially harmed.
 
Because we and our collaborative partners have not begun commercial sales of our products, our revenue and profit potential are unproven and our limited operating history makes it difficult for an investor to evaluate our business and prospects. Our technology may not result in any meaningful benefits to our current or potential collaborative partners. Further, due to our limited operating history, we have difficulty accurately forecasting our revenue. Our business and prospects should be considered in light of the heightened risks and unexpected expenses and problems we may face as a company in an early stage of development in a new and rapidly evolving industry.
 
We have incurred large operating losses and these losses may continue.
 
We have incurred large operating losses and these losses may continue. In particular, as of March 31, 2002, we had an accumulated deficit of approximately $141.9 million. Our losses have resulted principally from:
 
 
•
 
research and development costs relating to the development of our technology and antibody product candidates;
 
 
•
 
costs associated with the establishment of our new laboratory and manufacturing facilities and manufacturing of products; and
 
 
•
 
general and administrative costs relating to our operations.
 
We intend to continue to make significant investments in:
 
 
•
 
research and development;
 
 
•
 
preclinical testing and clinical trials;
 
 
•
 
establishing new collaborations;
 
 
•
 
investing in new technologies; and
 
 
•
 
expanding of our manufacturing and production capabilities.
 
We do not know when or if we or our partners will complete any pending or future product development efforts, receive regulatory approval or successfully commercialize any approved products. We may continue to incur substantial operating losses even if our revenues increase. As a result, we cannot predict the extent of future losses or the time required for us to achieve profitability, if at all.

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Our operating results may vary significantly from period-to-period.
 
Our future revenues and operating results are expected to vary significantly from period-to-period due to a number of factors. Many of these factors are outside of our control. These factors include:
 
 
•
 
the timing of the commencement, completion or termination of collaborative agreements;
 
 
•
 
the introduction of new products and services by us, our collaborative partners or our competitors;
 
 
•
 
delays in preclinical testing and clinical trials;
 
 
•
 
changes in regulatory requirements for clinical trials;
 
 
•
 
costs and expenses associated with preclinical testing and clinical trials;
 
 
•
 
the timing of regulatory approvals, if any;
 
 
•
 
sales and marketing expenses; and
 
 
•
 
the amount and timing of operating costs and capital expenditures relating to the expansion of our business operations and facilities.
 
Period-to-period comparisons of our results of operations may not be relied upon as an indication of future performance.
 
It is possible that in some future periods, our operating results may be below expectations of analysts and investors. If this happens, the price of our common stock may decrease.
 
Clinical trials required for our product candidates are expensive and time-consuming and their outcome is uncertain.
 
The testing of product candidates employing our human antibody technology must demonstrate that they are safe and effective for use in humans through preclinical testing and clinical trials in order to be approved for commercial sale. For biological products, safety, purity and potency must also be demonstrated. Conducting clinical trials is a lengthy, time-consuming and expensive process. The length of time may vary substantially according to the type, complexity, novelty and intended use of the product candidate, and often can be several years or more. Delays associated with products for which we are directly conducting preclinical or clinical trials may cause us to incur additional operating expenses. Moreover, we will continue to be subject to the preclinical testing and clinical trials of certain product candidates conducted by our licensees and collaborative partners over which we have no control. The commencement and rate of completion of clinical trials may be delayed by many factors, including:
 
 
•
 
the inability to manufacture sufficient quantities of qualified materials under current good manufacturing practices, or cGMPs, for use in clinical trials;
 
 
•
 
slower than expected rates of patient recruitment;
 
 
•
 
the inability to adequately observe patients after treatment;
 
 
•
 
changes in regulatory requirements for clinical trials;
 
 
•
 
the lack of effectiveness during the clinical trials;
 
 
•
 
unforeseen safety issues; and
 
 
•
 
government or regulatory delays.
 
Even if we obtain positive results from preclinical or clinical trials, we may not achieve the same success in future trials. Clinical trials may not demonstrate statistically sufficient safety and effectiveness to obtain the requisite regulatory approvals for product candidates employing our human antibody technology. The failure of clinical trials to demonstrate safety and effectiveness for our desired indications

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could harm the development of that product candidate as well as other product candidates, and our business and results of operations will suffer.
 
Success in early clinical trials may not be indicative of results obtained in later trials.
 
Results of our early clinical trials and those of our partners’ using our human antibody technology are based on a limited number of patients and may, upon review, be revised or negated by authorities or by later stage clinical results. Historically, the results from preclinical testing and early clinical trials have often not been predictive of results obtained in later clinical trials. A number of new drugs and biologics have shown promising results in clinical trials, but subsequently failed to establish sufficient safety and effectiveness data to obtain necessary regulatory approvals. Data obtained from preclinical and clinical activities are susceptible to varying interpretations, which may delay, limit or prevent regulatory approval. In addition, regulatory delays or rejections may be encountered as a result of many factors, including changes in regulatory policy during the period of product development.
 
Product candidates employing our antibody technology may fail to gain market acceptance.
 
Even if clinical trials demonstrate the safety and efficacy of products developed by us or our corporate partners using our technology and all regulatory approvals have been obtained, product candidates employing our antibody technology may not gain market acceptance among physicians, patients, third-party payors and the medical community. For example, the current delivery systems for antibody-based therapeutic products are intravenous and subcutaneous injection, which are generally less well received by patients than tablets or capsule delivery. The degree of market acceptance of any product candidates employing our technology will depend on a number of factors, including:
 
 
•
 
establishment and demonstration of clinical efficacy, potency and safety, especially as compared to conventional treatments;
 
 
•
 
cost-effectiveness;
 
 
•
 
alternative treatment methods;
 
 
•
 
reimbursement policies of government and third-party payors; and
 
 
•
 
marketing and distribution support for our product candidates.
 
In addition, many of our activities involve genetic engineering in animals and animal testing. These types of activities have been the subject of controversy and adverse publicity. Animal rights groups and various other organizations and individuals have attempted to stop genetic engineering activities and animal testing by lobbying for legislation and regulation in these areas.
 
 
If products employing our technology do not achieve significant market acceptance, our business will suffer.
 
The successful commercialization of our antibody products will depend on obtaining coverage and reimbursement for use of these products from third-party payors.
 
Sales of pharmaceutical products largely depend on the reimbursement of patients’ medical expenses by government health care programs and private health insurers. Without the financial support of the governments or third-party payors, the market for products employing our human antibody technology will be limited. These third-party payors are increasingly challenging the price and examining the cost effectiveness of medical products and services. In addition, significant uncertainty exists as to the reimbursement status of newly approved healthcare products. We may need to conduct post-marketing studies in order to demonstrate the cost-effectiveness of our products. Such studies may require us to provide a significant amount of resources. Our project candidates may not be considered cost-effective. Third-party payors may not reimburse sales of products employing our human antibody technology, or enable us or our corporate partners to sell them at profitable prices.

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Third-party payors control health care costs by limiting both coverage and the level of reimbursement for new health care products. In the future, the United States government may institute price controls and further limits on Medicare and Medicaid spending. Internationally, medical reimbursement systems vary with differing degrees of regulation. Pricing controls and reimbursement limitations could affect the payments we receive from sales of products employing our human antibody technology. These variations could harm our ability and the ability of our corporate partners to sell products employing our human antibody technology in commercially acceptable quantities at profitable prices.
 
We have limited manufacturing capabilities.
 
To be successful, our therapeutic products must be manufactured in commercial quantities in compliance with regulatory requirements and at acceptable costs. While we believe our current facilities are adequate for the limited production of product candidates for clinical trials, our facilities are not adequate to produce sufficient quantities of any products for commercial sale.
 
 
If we are unable to establish and maintain a manufacturing facility or secure third party manufacturing capacity within our planned time and cost parameters, the development and sales of our products and our financial performance may be materially harmed.
 
We may also encounter problems with the following:
 
 
•
 
production yields;
 
 
•
 
quality control and assurance;
 
 
•
 
shortages of qualified personnel;
 
 
•
 
compliance with FDA regulations;
 
 
•
 
production costs; and
 
 
•
 
development of advanced manufacturing techniques and process controls.
 
We are aware of only a limited number of companies on a worldwide basis that operate manufacturing facilities in which our product candidates can be manufactured under cGMP regulations, a requirement for all pharmaceutical products. It would take a substantial period of time for a contract facility that has not been producing antibodies to begin producing antibodies under cGMP regulations. We cannot make assurances that we will be able to contract with any of these companies on acceptable terms or in a timely manner, if at all.
 
In addition, we and any third-party manufacturer will be required to register manufacturing facilities with the FDA and other regulatory authorities. The facilities will be subject to inspections confirming compliance with cGMP or other regulations. If we or any of our third-party manufacturers fail to maintain regulatory compliance, our business, financial condition and results of operations may be materially harmed and the FDA can impose regulatory sanctions.
 
We have no sales or marketing experience.
 
We currently have no sales, marketing or distribution capabilities. We may need to enter into arrangements with third parties to market and sell certain of our products. We may not be able to enter into marketing and sales arrangements with others on acceptable terms, if at all. To the extent that we enter into marketing and sales arrangements with other companies, our revenues, if any, will depend on the efforts of others. These efforts may not be successful. We may choose to market some of our products directly through a sales and marketing force. In order to do this, we will have to develop a sales and marketing staff and establish distribution capability. Developing a sales and marketing force would be expensive and time-consuming and could delay any product launch. If we choose to market any of our products directly but are unable to successfully implement a marketing and sales force, our business and operating results will be harmed.
 

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We are, in part, dependent on our collaborative and licensing partners to support our business and to develop products employing our human antibody technology.
 
We depend on our collaborative and licensing partners to support our business and to develop products employing our antibody technology. We currently, or in the future may, rely on our collaborative and licensing partners to:
 
 
•
 
access proprietary antigens for the development of product candidates;
 
 
•
 
access skills and information that we do not possess;
 
 
•
 
fund our research and development activities;
 
 
•
 
manufacture products;
 
 
•
 
fund and conduct preclinical testing and clinical trials;
 
 
•
 
seek and obtain regulatory approvals for product candidates; and
 
 
•
 
commercialize and market future products.
 
Our dependence on our collaborative and licensing partners subjects us to a number of risks, including:
 
 
•
 
our collaborative and licensing partners have significant discretion whether to pursue planned activities;
 
 
•
 
we cannot control the quantity and nature of the resources our collaborative and licensing partners may devote to product candidates;
 
 
•
 
our collaborators may not develop products employing our antibody technology as expected; and
 
 
•
 
business combinations or significant changes in a collaborative and licensing partner’s business strategy may adversely affect that partner’s willingness or ability to continue to pursue these product candidates.
 
If we do not realize the contemplated benefits from our collaborators, our business will suffer.
 
Our existing collaborative and licensing partnerships may not be completed or may be terminated, and we may not be able to establish additional collaborative or licensing partnerships.
 
We have entered into binding letters of intent or memoranda of understanding with Eos Biotechnology, Inc., Genmab A/S, Kirin Brewery Co., Ltd., Immusol, Inc., Athersys, Inc., and Regeneron Pharmaceuticals, Inc. These binding letters of intent or memoranda of understanding include the principal terms of these transactions, which will be incorporated into definitive agreements. By their terms, these letters of intent and memoranda of understanding will remain in full force and effect and the parties will operate in accordance with their terms until such time as definitive agreements are executed. If we are unable to agree on the terms of a definitive agreement with respect to one or more of these partners, our business may be harmed.
 
Our partners generally have the right to terminate our partnerships at any time. Lengthy negotiations with potential new partners or disagreements between us and our partners may lead to delays or termination in the research, development or commercialization of product candidates. If we are not able to establish additional collaboration or licensing partnerships on terms that are favorable to us or if a significant number of our existing corporate partnerships are terminated and we cannot replace them, we may be required to increase our internal product development and commercialization efforts. This would likely:
 
 
•
 
limit the number of product candidates that we will be able to develop and commercialize;
 
 
•
 
significantly increase our need for capital; and

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•
 
place additional strain on management’s time.
 
Any of the above may harm our business.
 
Our goals and/or strategy may conflict with those of our collaborative or licensing partners.
 
We may have goals and/or strategies that may conflict with those of our partners that could adversely affect our business. For example, our collaborative or licensing partners may pursue alternative technologies, including those of our competitors. Disputes may arise with respect to the ownership of rights to any technology or products developed with any licensing or collaborative partner. If our partners pursue alternative technologies or fail to develop or commercialize successfully any product candidate to which they have obtained rights from us, our business will suffer.
 
We have a significant minority interest in two entities. There may be conflicts of interest between us and these entities.
 
We currently have an equity interest of approximately 31% in Genmab, which intends to develop and commercialize a portfolio of fully human antibodies derived from our human antibody technology. In addition, we have an equity position in Immuno-Designed Molecules S.A., or IDM, of approximately 6%. In the event that we exercise certain warrants held by us to purchase convertible or redeemable bonds of IDM and such bonds are converted or redeemed, our equity position in IDM would be approximately 29%, based on the shares currently outstanding. These warrants are exercisable between September 2002 and September 2010, and such bonds may be converted or redeemed within six months of such exercise. Each of IDM and Genmab intends to develop and commercialize a portfolio of antibody-based products.
 
Due to the size of our interest in Genmab, we are currently required to account for our equity interest in Genmab under the equity method of accounting, which provides that we must include a portion of Genmab’s income and losses equal to our percentage equity interest in Genmab in our consolidated financial statements. For the years ended December 31, 1999, 2000 and 2001, our share of Genmab’s losses were $0, $353,000 and $7,334,000 respectively. For the three month period ended March 31, 2002, our share of Genmab’s net loss was $3,589,000. Genmab has stated that it anticipates that it will incur substantial losses as it expands its research and product development efforts. As Genmab’s losses continue to increase, the aggregate amount of such losses we must include in our consolidated financial statements will also increase.
 
We are dependent on our key personnel.
 
We are highly dependent on the members of our scientific and management staff. If we are not able to retain any of these persons, our business may suffer. In particular, we depend on the services of Donald L. Drakeman, our President and Chief Executive Officer, and Nils Lonberg, Ph.D., Senior Vice President and Scientific Director. For us to pursue product development, marketing and commercialization plans, we will need to hire additional qualified scientific personnel to perform research and development. We will also need to hire personnel with expertise in clinical testing, government regulation, manufacturing, marketing and finance. We may not be able to attract and retain personnel on acceptable terms, given the competition for such personnel among biotechnology, pharmaceutical and healthcare companies, universities and non-profit research institutions. If we are not able to attract and retain qualified personnel, our business will suffer.
 
We depend on patents and proprietary rights.
 
Our success depends in part on our ability to:
 
 
•
 
protect trade secrets;
 
 
•
 
operate without infringing upon the proprietary rights of others; and
 
 
•
 
apply for, obtain, protect and enforce patents.
 

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We will be able to protect our proprietary rights from unauthorized use by third parties only to the extent that our proprietary rights are covered by valid and enforceable patents or are effectively maintained as trade secrets. We protect our proprietary position by filing United States and foreign patent applications related to our proprietary technology, inventions and improvements that are important to the development of our business. While a number of patents have been issued in the United States and Europe relating to our human antibody technology, we may not be able to obtain patent protection in other countries. Our pending patent applications, those we may file in the future, or those we may license from third parties, may not result in patents being issued. The patent position of biotechnology companies involves complex legal and factual questions and, therefore, enforceability cannot be predicted with certainty. Patents, if issued, may be challenged, invalidated or circumvented. Thus, any patents that we own or license from third parties may not provide sufficient protection against competitors. Also, patent rights may not provide us with proprietary protection or competitive advantages against competitors with similar technology. Furthermore, others may independently develop similar technologies or duplicate any technology that we have developed. The laws of foreign countries may not protect our intellectual property rights to the same extent as do the laws of the United States.
 
In addition to patents, we rely on trade secrets and proprietary know-how. We seek protection, in part, through confidentiality and proprietary information agreements. These agreements may not provide protection or adequate remedies for our human antibody technology in the event of unauthorized use or disclosure of confidential and proprietary information, or breach of these agreements. Furthermore, our trade secrets may otherwise become known to, or be independently developed by, our competitors.
 
Our commercial success depends significantly on our ability to operate without infringing the patents and other proprietary rights of third parties. In the event that our technologies may infringe on the patents or violate other proprietary rights of third parties, we and our corporate partners may be prevented from pursuing product development, manufacturing or commercialization. Such a result would harm our business.
 
The biotechnology and pharmaceutical industries have been characterized by extensive litigation regarding patents and other intellectual property rights. The defense and prosecution of intellectual property disputes are costly and time-consuming to pursue and their outcome is uncertain.
 
If we become involved in any litigation, interference or other judicial or administrative proceedings, we will incur substantial expense and the efforts of our technical and management personnel will be diverted. An adverse determination may subject us to significant liabilities or require us to seek licenses that may not be available from third parties on commercially favorable terms, if at all. Therefore, we and our collaborative partners may be restricted or prevented from manufacturing and selling products employing our human antibody technology, which would harm our business.
 
 
Even though we have received patents pertaining to the HuMAb-Mouse technology, this does not mean that we and our permitted licensees of HuMAb-Mouse technology will have exclusive rights to antibodies against all targets that are made using this technology, or that we or our licensees will have the right to make, develop, use or sell such antibodies.
 
Our patents covering the HuMAb-Mouse technology include patents that cover particular human monoclonal antibodies. These patents do not cover all human antibodies.
 
Our patents may not protect against the importation of products, such as antibodies, made using HuMAb-Mouse technology.
 
Moreover, other parties could have blocking patent rights to products made using HuMAb-Mouse technology, such as antibodies, and their production and uses, either because of a proprietary position covering the antibody or the antibody’s target. For example, we are aware of certain United States and European patents held by third parties relating to particular targets for their human monoclonal antibodies, to human monoclonal antibodies against various targets and biospecific products, and the manufacture and use of such products. In particular, we are aware of certain United States and foreign patents owned by a third party that pertain to monoclonal antibodies against CTLA-4 and their uses. We

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are also aware of certain United States and foreign patents held by third parties relating to particular anti-CD4 antibodies, anti-EGFr antibodies, anti-PSMA antibodies, and anti-heparanase antibodies.
 
We are also aware of a United States patent owned by Genentech relating to the production of recombinant antibodies in host cells. We currently produce certain of our products and our partners’ products using recombinant antibodies from host cells and may choose to produce additional products in this manner. If any of our antibody products are produced in the manner claimed in this patent, then we may need to obtain a license, should one be available. If we are unable to obtain a license on commercially reasonable terms, we may be impaired from making recombinant antibodies using Genentech’s techniques. In addition to the Genentech patent, we are also aware of certain United States patents held by third parties relating to antibody expression in particular types of host cells which may be relevant to our future manufacturing techniques.
 
If our antibody products (or those antibody products of our partners using our human antibody technology) or their commercial use or production meet all of the requirements of any of the claims of the aforementioned patents, or patents which may issue from the aforementioned patent applications, then we or our partners may need a license to one or more of these patents. Further, we are aware of a number of other third party patent applications which, if granted, with claims as currently drafted, may cover our and our partners’ current or planned activities. We seek to obtain licenses to such patents when, in our judgment, such licenses are needed. If any licenses are required, there can be no assurance that we will be able to obtain any such license on commercially favorable terms, if at all, and if these licenses are not obtained, we might be prevented from using certain of our technologies for the generation of our recombinant human antibody products. Our failure to obtain a license to any technology that we may require may have a material adverse effect on our business, financial condition and results of operations. We cannot assure you that our products and/or actions in developing or selling its recombinant human antibody products will not infringe such patents.
 
In general, our patent protection may not prevent others from developing competitive products using our technology or other technologies. Similarly, others may obtain patents that could limit our ability and the ability of our licensees to use, import, manufacture, market or sell products or impair our competitive position and the competitive position of our licensees.
 
We are not the exclusive owner of the technology underlying our HuMAb-Mice. In March 1997, prior to our acquisition of GenPharm International, Inc., GenPharm entered into a cross-license and settlement agreement with Abgenix, Inc., Cell Genesys, Inc., Xenotech, L.P. and Japan Tobacco, Inc., pursuant to which Abgenix and these entities paid us and GenPharm a total of approximately $38.6 million during 1997 and 1998. This payment was in exchange for a non-exclusive license to certain patents, patent applications, third-party licenses and inventions pertaining to the development and use of certain transgenic rodents, including mice, that produce fully human antibodies that are integral to our products and business. These patents, licenses and inventions form the basis of our HuMAb-Mouse technology. Our business may suffer from the competition of these entities or if any of these entities breach the cross-license and settlement agreement.
 
We are not the exclusive owner of the technology underlying the TC Mouse or the KM-Mouse. In December 1999, we entered into a binding letter of intent with Kirin. Under the terms of this letter of intent, Kirin was designated as the primary distributor of our HuMAb-Mouse technology in Asia, and we were designated as the primary distributor of Kirin’s TC Mouse outside of Asia. However, Kirin has certain rights to distribute the TC Mouse and the crossbred mouse throughout the world. We have exchanged broad licenses with Kirin, subject to milestone and royalty payments, for use of each other’s technology for the development of human antibody therapeutic products. The binding letter of intent with Kirin includes a license to certain patents, patent applications, third-party licenses and inventions pertaining to the development and use of the TC Mouse and the KM-Mouse. Our business may suffer from the competition of Kirin.

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We may face product liability claims related to the use or misuse of products employing our antibody technology.
 
The administration of drugs to humans, in clinical trials or after commercialization, may expose us to product liability claims. Consumers, healthcare producers or persons selling products based on our technology may be able to bring claims against us based on the use of our products in clinical trials and the sale of products based on our technology. Product liability claims may be expensive to defend and may result in large judgments against us. In November 1998, we voluntarily suspended clinical trials for one of our products after some patients experienced serious adverse events, or SAEs. As a result of these SAEs, we have received a small number of claims, of which four have resulted in lawsuits being filed. All of these lawsuits have been settled for insubstantial amounts. We currently maintain liability insurance with specified coverage limits. Although we believe these coverage limits are adequate, we cannot be certain that the insurance policies will be sufficient to cover all claims that may be made against us. Product liability insurance is expensive, difficult to obtain and may not be available in the future on acceptable terms. Any claims against us, regardless of their merit, could harm our business, financial condition and results of operations.
 
We face intense competition and rapid technological change.
 
The development of biotechnology and pharmaceutical products is a highly competitive business subject to significant and rapid technological change. We face competition in several different forms. First, our human antibody development activities currently face competition from several competitors and from other technologies. The actual products being developed by our collaborators or by us also face actual and potential competition. Developments by our competitors may render our human antibody technology obsolete or non-competitive.
 
We are aware of several pharmaceutical and biotechnology companies which are actively engaged in research and development in areas related to antibody therapy. Some of these companies have commenced clinical trials of antibody products or have successfully commercialized antibody products. Many of these companies are addressing the same diseases and disease indications as we and our corporate partners. Also, we compete with companies that offer antibody generation services to companies that have antigens. These competitors have specific expertise or technology related to antibody development. We compete directly with Abgenix, with respect to the generation of fully human antibodies from transgenic mice. In addition, we have entered into agreements with each of Kirin and Genmab, respectively, which grant these companies licenses to our proprietary technology platform, enabling them to compete with us in offering antibody generation and development services in certain markets. Xenerex Biosciences and XTL Biopharmaceutical, Ltd. have developed technology that, according to Xenerex and XTL, will allow them to generate fully human monoclonal antibodies. Numerous additional companies are developing therapeutic products comprising human antibody components. Furthermore, several companies are developing, or have developed, technologies that do not involve immunization of animals for creating synthetic antibodies comprising human antibody sequence. For example, phage and yeast display technology is being used by companies, such as Abbott Laboratories, Inc., Cambridge Antibody Technology Group plc, or CAT, Dyax Corp., Genetastic, Inc. and MorphoSys AG to develop therapeutic products comprising human antibody sequences. Companies such as Johnson & Johnson, Medimmune, Inc., Immunex, IDEC Pharmaceuticals Corporation, Novartis, Genentech, Inc., Protein Design Labs, Inc. and Wyeth have generated therapeutic products derived from recombinant DNA that comprise human antibody components that are currently being marketed.
 
Other technologies can also be applied to the treatment of the diseases that we or our corporate partners are pursuing. For example, immunoconjugates—monoclonal antibodies linked to toxins or radioactive isotypes—are being developed by others. In addition, the application of recombinant DNA technology to develop potential products consisting of proteins (such as growth factors, hormones, enzymes, receptor fragments and fusion proteins, or cytokines) that do not occur normally in the body, or occur only in small amounts, has been underway for some time. Included in this group are interleukins such as IL-2 and IL-11, interferons alpha, beta and gamma, colony stimulating factors such as G-CSF and GM-CSF, clotting factors, growth hormones, erythropoeitin, DNAse, tPA, glucocerebrosidase, PDGF, and a number of other biological response modifiers. Continuing development of conventional new chemical entities and other drugs by large pharmaceutical companies carries with it the potential for

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discovery of agents for treating disease indications also targeted by drugs that we or our partners are developing.
 
Some of our competitors have received regulatory approval or are developing or testing product candidates that compete directly with product candidates employing our antibody technology. Many of these companies and institutions, either alone or together with their corporate partners, have substantially greater financial resources and larger research and development staffs than we or some of our corporate partners do. In addition, many of these competitors have significantly greater experience than we do in:
 
 
•
 
developing products;
 
 
•
 
undertaking preclinical testing and clinical trials;
 
 
•
 
obtaining FDA and other regulatory approvals of products; and
 
 
•
 
manufacturing and marketing products.
 
Accordingly, our competitors may obtain patent protection, receive FDA approval or commercialize products before we or our corporate partners do. If we or our corporate partners commence commercial product sales, we or our corporate partners will be competing against companies with greater marketing and manufacturing capabilities, areas in which we and certain of our corporate partners have limited or no experience.
 
We also face intense competition from other pharmaceutical and biotechnology companies to establish corporate partnerships, as well as relationships with academic and research institutions, and to license proprietary technology. These competitors, either alone or with their corporate partners, may succeed in developing technologies or products that are more effective than ours.
 
If our operating losses are greater than anticipated, we may need substantial additional funding. We may not be able to obtain sufficient funds to grow our business or continue our operations.
 
We will continue to expend substantial resources for research and development, including costs associated with developing our antibody technology and conducting preclinical testing and clinical trials. Our future capital requirements will depend on:
 
 
•
 
the size and complexity of research and development programs;
 
 
•
 
the scope and results of preclinical testing and clinical trials;
 
 
•
 
the retention of existing and establishment of further corporate partnerships, if any;
 
 
•
 
continued scientific progress in our research and development programs;
 
 
•
 
the time and expense involved in seeking regulatory approvals;
 
 
•
 
competing technological and market developments;
 
 
•
 
the time and expense of filing and prosecuting patent applications and enforcing patent claims; and
 
 
•
 
the cost of establishing manufacturing capabilities, conducting commercialization activities and arrangements and in-licensing products.
 
We may be unable to raise sufficient funds to complete development of any of our product candidates or to continue operations. As a result, we may face delay, reduction or elimination of research and development programs or preclinical or clinical trials, in which case our business will suffer.
 
We are subject to extensive and costly government regulation.
 
Product candidates employing our human antibody technology are subject to extensive and rigorous domestic government regulation. The FDA regulates the research, development, preclinical and clinical testing, manufacture, safety, effectiveness, record-keeping, reporting, labeling, storage, approval,

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advertising, promotion, sale, distribution, import, and export of biopharmaceutical products. The FDA regulates human antibodies as biologics, subject to a Biologic License Application, or BLA, under the Public Health Services Act, as amended. If products employing our human antibody technology are marketed abroad, they will also be subject to extensive regulation by foreign governments. Government regulation substantially increases the cost of researching, developing, manufacturing, and selling our products. The regulatory review and approval process, which includes preclinical testing and clinical trials of each product candidate, is lengthy, expensive and uncertain. We or our corporate partners must obtain regulatory approval for each product we intend to market, and the manufacturing facilities used for the products must be inspected and meet legal requirements. Securing regulatory approval requires the submission of extensive preclinical and clinical data and other supporting information for each proposed therapeutic indication in order to establish the product’s safety, potency and efficacy for its intended uses. The approval process takes many years, requires substantial resources, and may never lead to the approval of a product. Failure to obtain regulatory approvals, or delays in obtaining regulatory approvals may:
 
 
•
 
adversely affect the successful commercialization of any drugs that we or our corporate partners develop;
 
 
•
 
impose additional costs on us or our corporate partners;
 
 
•
 
diminish any competitive advantages that we or our corporate partners may attain; and
 
 
•
 
adversely affect our receipt of revenues or royalties.
 
Even if we are able to obtain regulatory approval for a particular product, the approval may limit the indicated uses for the product, may otherwise limit our ability to promote, sell, and distribute the product, may require that we conduct costly post-marketing surveillance, and/or may require that we conduct ongoing post-marketing studies. Material changes to an approved product, such as, for example, manufacturing changes or revised labeling, may require further regulatory review and approval. Once obtained, any approvals may be withdrawn, including, for example, if there is a later discovery of previously unknown problems with the product, such as a previously unknown safety issue. If we, our corporate partners or our contract manufacturers fail to comply with applicable regulatory requirements at any stage during the regulatory process, such noncompliance could result in, among other things:
 
 
•
 
delays in the approval of applications or supplements to approved applications;
 
 
•
 
refusal of a regulatory authority, including the FDA, to review pending market approval applications or supplements to approved applications;
 
 
•
 
warning letters;
 
 
•
 
fines;
 
 
•
 
import and/or export restrictions;
 
 
•
 
product recalls or seizures;
 
 
•
 
injunctions;
 
 
•
 
total or partial suspension of production;
 
 
•
 
civil penalties;
 
 
•
 
withdrawals of previously approved marketing applications or licenses;
 
 
•
 
recommendations by the FDA or other regulatory authorities against governmental contracts; and
 
 
•
 
criminal prosecutions.
 
In certain cases, we expect to rely on our corporate partners to file INDs with the FDA and to direct the regulatory approval process for products employing our human antibody technology. Our corporate partners may not be able to conduct clinical testing or obtain necessary approvals from the FDA or other regulatory authorities for their product candidates employing our human antibody

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technology. If they fail to obtain required governmental approvals, our corporate partners will be delayed or precluded from marketing these products. As a result, commercial use of products employing our technology will not occur and our business may be harmed.
 
We do not have, and may never obtain, the regulatory approvals we need to market our product candidates.
 
To date, we have not applied for or received the regulatory approvals required for the commercial sale of any of our products in the United States or in any foreign jurisdiction. None of our product candidates has been determined to be safe and effective, and we have not submitted a New Drug Application, or NDA, or BLA, to the FDA or to any foreign regulatory authorities for any of our product candidates. We have only limited experience in filing and pursuing applications necessary to obtain regulatory approval, and none of our product candidates may be approved for marketing.
 
Product candidates that appear promising in the early phases of development, such as in early human clinical trials, may fail to reach the market for a number of reasons, such as the product candidate did not demonstrate acceptable clinical trial results even though it demonstrated positive preclinical trial results; the product candidate was not effective in treating the specified disease or condition; the product candidate had harmful side effects on humans or presented unacceptable safety risks; the governing regulatory authorities (such as FDA) denied approval to the product candidate altogether or denied a commercially important indicated use; the product candidate was not economical for us to manufacture; and/or the product candidate was not cost effective in light of alternative therapies. We cannot guarantee that we will ever be able to produce commercially successful products.
 
If we or our manufacturing partners do not obtain or maintain current Good Manufacturing Practices, we may not be able to commercialize our product candidates.
 
We will depend on our own manufacturing facilities and on those of our corporate partners and other third parties to manufacture products employing our human antibody technology. Before commercializing a new drug, manufacturers must demonstrate compliance with the applicable cGMP regulations which include quality control and quality assurance requirements as well as the maintenance of extensive records and documentation. Manufacturing facilities are subject to ongoing periodic inspection by the FDA and corresponding foreign and state authorities, including unannounced inspections, and must be licensed before they can be used in commercial manufacturing for products employing our technology. In addition, cGMP requirements are constantly evolving, and new or different requirements may apply in the future. We, our partners or third party contract manufacturers may not be able to comply with the applicable regulations. After regulatory approvals are obtained, the subsequent discovery of previously unknown problems, or the failure to maintain compliance with existing or new regulatory requirements, may result in restrictions on the marketing of a product, withdrawal of the product from the market, seizures, the shutdown of manufacturing facilities, injunctions, monetary fines and/or civil or criminal sanctions.
 
Our operations involve hazardous materials and are subject to environmental controls and regulations.
 
As a biopharmaceutical company, we are subject to environmental and safety laws and regulations, including those governing the use of hazardous materials. The cost of compliance with health and safety regulations is substantial. Our business activities involve the controlled use of hazardous materials and we cannot eliminate the risk of accidental contamination or injury from these materials. In the event of an accident or environmental discharge, we may be held liable for any resulting damages, which may exceed our financial resources and may materially adversely affect our business, financial condition and results of operations.
 
If our license agreements violate the competition provisions of the Treaty of Rome, then some terms of our key agreements may be unenforceable.
 
Certain license agreements that we have entered into or may enter into will grant or may grant exclusive worldwide licenses of patents, patent applications and know-how, which are or may be arguably

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restrictive of competition under Article 81(1) of the Treaty of Rome. Article 81(1) prohibits agreements which restrict competition within the European Community and affect trade between member states. We determine on an agreement-by-agreement basis where an exemption from the application of Article 81(1) applies to the agreement and, if it does not, whether to apply to the European Commission for an individual exemption from the application of Article 81(1). If an exemption is not applicable and we do not apply for, or are unsuccessful in obtaining, an exemption from the European Commission, provisions of any license agreement which are found to be restrictive of competition under Article 81(1), including those relating to the exclusivity of rights, may be unenforceable and we could lose the benefit of the rights granted under the provisions.
 
Our stock price may be volatile.
 
There has been significant volatility in the market prices of biotechnology companies’ securities. Various factors and events may have a significant impact on the market price of our common stock. These factors include:
 
 
•
 
fluctuations in our operating results;
 
 
•
 
announcements of technological innovations or new commercial therapeutic products by us or our competitors;
 
 
•
 
published reports by securities analysts;
 
 
•
 
progress with clinical trials;
 
 
•
 
governmental regulation;
 
 
•
 
developments in patent or other proprietary rights;
 
 
•
 
developments in our relationship with collaborative partners;
 
 
•
 
public concern as to the safety and effectiveness of our products; and
 
 
•
 
general market conditions.
 
The trading price of our common stock has been, and could continue to be, subject to wide fluctuations in response to these or other factors, including the sale or attempted sale of a large amount of our common stock into the market. Broad market fluctuations may also adversely affect the market price of our common stock.
 
We have obligations to issue shares of our common stock in the future, which may have a dilutive effect on the shares of our common stock currently outstanding.
 
As of July 15, 2002, we have 9,744,331 shares of common stock reserved for issuance pursuant to options, which have been granted under our stock option plans having a weighted average exercise price of $13.99 per share. In addition, as of that date, there are 912,490 shares reserved for issuance pursuant to a deferred compensation plan. The shares reserved for the deferred compensation plan will be issued in various amounts over various periods of time during the next five years. We have filed a registration statement on Form S-8 covering those shares. Shares issued pursuant to this plan, other than shares issued to affiliates, will be freely tradable in the open market. Shares held by affiliates may be sold pursuant to the requirements of Rule 144.
 
In addition, as of July 15, 2002, we have reserved 1,760,600 shares of common stock for issuance pursuant to future grants of options under our stock option plans. We have filed registration statements on Form S-8 covering those shares. We have reserved 500,000 shares of common stock for issuance pursuant to our 2002 Employee Stock Purchase Plan. We have filed a registration statement on Form S-8 covering those shares. Shares issued under our plans, other than shares issued to affiliates, will be freely tradable on the open market.
 
The exercise of all or a portion of the outstanding options and warrants may result in a significant increase in the number of shares of our common stock that will be subject to trading on The Nasdaq

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National Market, or Nasdaq, and the issuance and sale of the shares of our common stock upon the exercise thereof may have an adverse effect on the price of our common stock.
 
As of July 15, 2002, we had 6,067,961 shares of common stock reserved for issuance pursuant to the conversion of $175,000,000 aggregate principal amount of our 4.50% Convertible Subordinated Notes due 2006. Holders of these notes may convert their notes into shares of common stock at any time prior to maturity or their redemption by us at a conversion rate of 34.6789 shares per each $1,000 principal amount of notes, subject to adjustment.
 
Pursuant to our license agreement with Novartis, Novartis may purchase $2,000,000 of our common stock at a price equal to one hundred and ten percent of the average of the closing sales prices of our common stock on Nasdaq, on the twenty consecutive days prior to the fifth anniversary (December 2003) of the agreement. Additionally, on the sixth anniversary of the agreement, Novartis may purchase $1,000,000 of our common stock at a price equal to one hundred and ten percent of the average of the closing sales prices of such stock on the Nasdaq on the twenty consecutive days prior to such anniversary.
 
Future sales of our common stock or other securities could cause the market price of our common stock to decline.
 
As of July 15, 2002, we have 74,881,177 shares of common stock outstanding, of which 2,131,629 are restricted securities as that term is defined in Rule 144 under the Securities Act. Under certain circumstances, these restricted securities may be sold without registration pursuant to such rule. We are unable to predict the effect that sales made under Rule 144 or pursuant to any registration may have on the market price of our common stock. The sale of a significant number of additional securities, or even the possibility thereof, may lower the market price of our common stock.
 
We have a filed registration statement on Form S-3 under the Securities Act relating to 3,791,346 shares of common stock that may be offered by one of our stockholders. These shares of common stock are freely tradable without restriction or further registration under the Securities Act except for shares held by our affiliates, which will be subject to resale limitations of Rule 144.
 
In addition, we have filed a shelf registration statement on Form S-3 under the Securities Act relating to the sale of up to $314.5 million of any of the following securities:
 
 
•
 
Debt Securities;
 
 
•
 
Preferred Stock;
 
 
•
 
Common Stock; or
 
 
•
 
Warrants to Purchase Debt Securities, Preferred Stock or Common Stock.
 
We have a significant amount of debt and may have insufficient cash to satisfy our debt service obligations. In addition, the amount of our debt could impede our operations and flexibility.
 
We have a significant amount of convertible debt and debt service obligations, which, unless converted to common shares of the Company, will mature in 2006. We may be unable to generate sufficient cash flow or otherwise obtain funds necessary to make required payments on our debt. Even if we are able to meet our debt service obligations, the amount of debt we have could adversely affect us in a number of ways, including by:
 
 
•
 
limiting our ability to obtain any necessary financing in the future for working capital, capital expenditures, debt service requirements or other purposes;
 
 
•
 
limiting our flexibility in planning for, or reacting to, changes in our business;
 
 
•
 
placing us at a competitive disadvantage relative to our competitors who have lower levels of debt;

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•
 
making us more vulnerable to a downturn in our business or the economy generally; and
 
 
•
 
requiring us to use a substantial portion of our cash to pay principal and interest on our debt, instead of applying those funds to other purposes such as working capital and capital expenditures.
 
Upon the occurrence of certain change of control events of our company, we are required to offer to repurchase all of our debt, which may adversely affect our business and the price of our common stock.
 
Upon the occurrence of certain change of control events of our company, we are required to offer to repurchase all of our outstanding 4.50% Convertible Subordinated Notes due 2006. As of June 30, 2002, $175,000,000 aggregate principal amount of the notes was outstanding. We may pay the repurchase price in cash or, at our option, in common stock. Such repurchase right may be triggered at a time at which we do not have sufficient funds available to pay the repurchase price in cash or determine that payment in cash is otherwise inadvisable. In such event, the issuance of a significant number of additional shares of common stock in payment of the repurchase price may lower the market price of our common stock.
 
 
Our restated certificate of incorporation, by-laws, stockholder rights plan and New Jersey law contain provisions that could delay or prevent an acquisition of our company.
 
In May 2001, our board of directors adopted a stockholder rights plan. The stockholder rights plan provides for a dividend of one preferred share purchase right on each outstanding share of our common stock. Each right entitles stockholders to buy 1/1000th of a share of our Series A junior participating preferred stock at an exercise price of $150.00. Each right will become exercisable following the tenth day after person or group announces an acquisition of 20% or more of our common stock. We will be entitled to redeem the rights at $0.001 per right at any time on or before the close of business on the tenth day following acquisition by a person or group of 20% or more of our common stock.
 
The stockholder rights plan and certain provisions of our restated certificate of incorporation and amended and restated by-laws may have the effect of making it more difficult for a third party to acquire, or of discouraging a third party from attempting to acquire control of us. This could limit the price that certain investors might be willing to pay in the future for our common stock.
 
The provisions of our restated certificate of incorporation and by-laws include:
 
 
•
 
a classified board of directors;
 
 
•
 
a requirement that special meetings of shareholders be called only by our board of directors, chairman of the board, chief executive officer or president;
 
 
•
 
advance notice requirements for shareholder proposals and nominations;
 
 
•
 
limitations on the ability of shareholders to amend, alter or repeal our by-laws; and
 
 
•
 
the authority of the board of directors to issue, without shareholder approval, preferred stock with such terms as the board of directors may determine.
 
We are also afforded the protections of the New Jersey Shareholders Protection Act. This New Jersey statute contains provisions that impose restrictions on shareholder action to acquire control of our company. The effect of the provisions of our restated certificate of incorporation and by-laws and New Jersey law may discourage third parties from acquiring control of our company.
 
We do not intend to pay cash dividends on our common stock in the foreseeable future.
 
We intend to retain any future earnings to finance the growth and development of our business and we do not plan to pay cash dividends on our common stock in the foreseeable future.
 

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USE OF PROCEEDS
 
We will not receive any cash proceeds from the issuance of the shares of our common stock pursuant to this offering. We will only receive certain assets from Corixa, valued at $21 million, including intellectual property, know-how, data, contracts and materials owned or licensed by Corixa related to certain product candidates and properties. For a more detailed description of this transaction see the section herein entitled “Recent Developments.”
 
PLAN OF DISTRIBUTION
 
The shares of common stock offered hereby are being issued directly to Corixa on the date of this prospectus supplement. No underwriters, agents, brokers or dealers were involved in the distribution of the shares of common stock offered hereby. No discounts, commissions, concessions or other compensation was paid to any underwriter, agent, broker or dealer in connection with the offering.
 
LEGAL MATTERS
 
The validity of the common stock offered hereby has been passed upon for us by Satterlee Stephens Burke & Burke LLP, New York, New York. Dwight A. Kinsey, Esq., a partner of Satterlee Stephens Burke & Burke LLP, owns 6,000 shares of our common stock. Mr. Kinsey also holds options to purchase 40,000 shares of our common stock which he received for service rendered as our Assistant Secretary. No other partner or associate of the firm owns shares or holds options to purchase any of our shares having a fair market value either individually or in the aggregate in excess of $50,000.
 
WHERE YOU CAN FIND MORE INFORMATION
 
A registration statement on Form S-3 (File No. 333-52696) with respect to the shares offered hereby (together with any amendments, exhibits and schedules thereto) has been filed with the SEC under the Securities Act. This prospectus supplement does not contain all of the information contained in such registration statement on Form S-3, certain portions of which have been omitted pursuant to the rules and regulation of the SEC. For further information with respect to us and the shares offered hereby, reference is made to the registration statement on Form S-3. Statements contained in this prospectus supplement regarding the contents of any contract or any other documents are not necessarily complete and, in each instance, reference is hereby made to the copy of such contract or document filed as an exhibit to the registration statement on Form S-3. The registration statement may be inspected without charge at the SEC’s principal office in Washington D.C., and copies of all or any part thereof may be obtained from the public reference facilities maintained by the SEC at 450 Fifth Street, NW, Judiciary Plaza, Washington D.C., 20549, upon payment of prescribed fees.
 
We also file annual, quarterly and special reports, proxy statements and other information with the SEC under the Exchange Act. The Exchange Act file number for our SEC filings is 0-19312. You may read and copy any document we file at the public reference facilities maintained by the SEC at 450 Fifth Street, NW, Judiciary Plaza, Washington D.C., 20549:
 
You may obtain information on the operation of the public reference room in Washington, D.C. by calling the SEC at 1-800-SEC-0330. We file information electronically with the SEC. Our SEC filings are available from the SEC’s Internet site at http://www.sec.gov, which contains reports, proxy and information statements and other information regarding issuers that file electronically. Our common stock is listed on the Nasdaq National Market under the symbol “MEDX.” You may read and copy our SEC filings and other information at the offices of Nasdaq Operations, 1735 K Street, N.W., Washington, D.C. 20006.

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INCORPORATION BY REFERENCE
 
The SEC allows us to “incorporate by reference” the documents we file with it, which means that we can disclose important information to you by referring you to those documents. The information in the documents incorporated by reference is considered to be part of this prospectus supplement, and information in the documents that we file later with the SEC will automatically update and supersede information in this prospectus supplement. We incorporate by reference the documents listed below and any future filings we will make with the SEC under Section 13(a), 13(c), 14 and 15(d) of the Exchange Act:
 
 
•
 
Annual Report on Form 10-K for the year ended December 31, 2001
 
 
•
 
Quarterly Report on Form 10-Q for the three months ended March 31, 2002
 
 
•
 
Current Report on Form 8-K filed on May 3, 2002
 
All documents filed by Medarex with the SEC pursuant to Section 13(a), 13(c), 14 or 15(d) of the Exchange Act subsequent to the date hereof and prior to the termination of the offering of the notes shall hereby be deemed to be incorporated by reference into this prospectus supplement and to be a part hereof from the date of filing of such documents. Any statement contained in a document incorporated or deemed to be incorporated by reference herein shall be deemed to be modified or superseded for purposes of this prospectus supplement to the extent that a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated by reference herein or in the accompanying prospectus modifies or supersedes such statement. Any such statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this prospectus supplement or the accompanying prospectus.
 
We will furnish our stockholders with annual reports that contain audited financial statements and quarterly reports for the first three quarters of each year that contain unaudited interim financial information.
 

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No dealer, salesperson or other person is authorized to give any information or to represent anything not contained in this prospectus. You must not rely on any unauthorized information or representations. This prospectus is an offer to sell only the securities offered hereby, but only under circumstances and in jurisdictions where it is lawful to do so. The information contained in this prospectus is current only as of its date.
 
 
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Prospectus Supplement
 
    
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464,437 Shares
 
Medarex, Inc.
 
Common Stock
 
 
PROSPECTUS SUPPLEMENT